Stuff Works
"I am totally satisfied with Zbiotics. As a woman about to turn 60, I still want to go out once in a while and have some wine. . . . not too much tho. This product ensures that I will feel fine the next day if I chose to drink alcohol."
ZBiotics® Pre-Alcohol Probiotic Drink breaks down a byproduct called acetaldehyde – the compound your body produces as it breaks down alcohol.
Couldn't load pickup availability
Free US shipping
100% money back guarantee

Gluten free
Nut free
Dairy free
Sugar free
Shellfish/Fish free
Vegan friendly
Third-party tested
Overall rating: 4.224876 / 5 from 2219 reviews.
ZBiotics® Pre-Alcohol Probiotic Drink aims to reduce the negative effects of alcohol consumption, particularly acetaldehyde. Customer feedback varies on its effectiveness, with some reporting reduced hangover symptoms and others experiencing no significant difference or even adverse effects.
Review topics: [improvement, results, feeling, issues, husband, packaging, bottle, works, amount, customer service, stomach, price, gift, relief, difference, service, delivery, drink, zbiotics, effect, alcohol, hangover, night, taste, friends, morning, water, sleep, science, shot].
"I am totally satisfied with Zbiotics. As a woman about to turn 60, I still want to go out once in a while and have some wine. . . . not too much tho. This product ensures that I will feel fine the next day if I chose to drink alcohol."
"Took this product on q 5 day vacation to cancun. Me and my wife took one each night before we started to indulged. Woke up the next day feeling good. Will be purchasing again. Thanks to Mindpump podcast for exposing me to this."
"Had a great week long celebration with my son and friends! We wanted to try all the wine they brought and of course a few martinis and limoncello spritzes. Everyone relied on Z to enjoy beers on the boat the next day!"
"It works! The recommendation was so resounding, and being an "old" now (I was called grandma for the 1st time the other day, I don't have grandchildren), drinking more than 1-2 drinks comes with regret now. It's not like I want the good ole days of heavy drinking with little to no consequences back, I just want to have a happy hour or brunch without having to plan a whole day or two for recovery. Thanks menopause. I've gotten days back with Pre-Alcohol! Thank you!"
"I admit I was somewhat skeptical that this would have any impact, but after the second night of taking it before drinks it really made a big difference the next morning! Felt as if I hadn't had any alcohol, which hasn't happened for a very long while!"
"Not sure if it actually works. I have taken it 3 times prior to drinking, and I don't feel any differences. From a return on investment perspective, I am not sure if this product makes sense. I don't think I will buy them again."
"My husband used this over the weekend, he thought he would not feel great Monday, but was pleasantly surprised to feel good all day."
"I use this before I drink EVERY time and never have a bad morning or a sleepless night. Don't save it for special occasions!"
"We used ZBiotics on a wine trip to France and the results were amazing. Have recommended to many friends!"
"My husband rarely drinks so he used these before wine tastings on our vacation, he felt great the next day. 10/10 recommend"
Check out our FAQs to find answers to common questions and feel free to reach out if you have more.
Pre-Alcohol is a beverage containing a patented, genetically engineered probiotic (B. subtilis ZB183™) that helps you land on your feet the day after drinking alcohol. It’s engineered to break down acetaldehyde – the compound your body produces as it breaks down alcohol.
Pre-Alcohol is designed to replicate the natural process of your liver, but do it in your gut. We took a normal probiotic bacteria you already eat every day, and we bioengineered it to produce the same type of enzyme your liver produces. That enzyme breaks down acetaldehyde – an unwanted byproduct of alcohol that accumulates in your gut when you drink.
Your liver does not have access to your gut. But by drinking Pre-Alcohol, the goal is to augment your gut’s natural ability to digest acetaldehyde while you drink and while you sleep – helping you make the most of the next day. Just remember that Pre-Alcohol does not affect intoxication or make alcohol safer to drink, so always drink responsibly.
When you're drinking. The earlier the better.
The probiotic in Pre-Alcohol needs time to “wake up” in your gut, so we say the earlier the better if you can remember it. We drink Pre-Alcohol just before going out – right before our first drink. But it should be active if you drink it any time during the day or evening. So whether it’s a few hours before drinking, right with your first drink, or even if you’ve already enjoyed a round or two, go for it.
The probiotic in Pre-Alcohol is likely to stay in your body for 18-24 hours after you drink it. So one bottle will cover you for a whole day, even if you're starting with brunch mimosas followed by evening plans later on!
Pre-Alcohol expires 18 months after bottling. Check the “BB” (Best-By) date on your bottle or box.
Store Pre-Alcohol at room temperature with the cap on. Do not refrigerate. Do not open it until you’re ready to drink it; opening it could potentially let contaminants from the air into the bottle.
Yes. Pre-Alcohol is fully FDA-compliant for safety and adheres to all regulatory requirements for sale in the U.S.
Note that FDA compliance is not FDA approval. FDA approval is a process reserved for drug products. Pre-Alcohol is a food/beverage product and has not been approved as efficacious for any purpose by the FDA.
FDA-compliant for safety means that we’ve satisfied all regulatory requirements to ensure Pre-Alcohol is safe and can be legally sold in the United States. That means that all our manufacturing is conducted in an FDA-registered food-grade facility according to Good Manufacturing Practices compliant with 21 CFR 117. It also means that our novel ingredient – Bacillus subtilis ZB183™ – has been extensively tested and is generally recognized, among qualified experts, as having been adequately shown to be safe under the conditions of its intended use.
No.
Pre-Alcohol will not affect your level of intoxication. Pre-Alcohol does not decrease your blood alcohol level, nor does it make alcohol any safer.
All the same rules about alcohol safety apply. Don’t get behind the wheel, don't operate heavy machinery, and don't drink too much. Alcohol is still dangerous on its own (citation).
That's not how it's designed.
We intentionally designed Pre-Alcohol so that it would not change your microbiome. We purposefully built our probiotic using a base bacteria that is well-adapted to passing straight through you and not colonizing your gut.
This creates a few likely benefits: (1) your microbiome remains unchanged; (2) the interaction between our probiotic and your gut should remain consistent and predictable; and (3) because we’re not trying to change your microbiome, we don’t need to use an excessive amount of probiotic per serving.
Yes!
We can confirm that Pre-Alcohol is free of all major allergens. Pre-Alcohol is tested, annually at minimum, against the allergens present in the manufacturing facility to ensure no cross-contamination. It does not contain:
Pre-Alcohol also doesn’t contain artificial flavors, and is vegan and vegetarian friendly.
Please note that our product contains live probiotic bacteria. As with any new food or supplement, it is always best to consult your medical doctor if you have any concerns related to your gut health with a new product.
Recommended pairing
Pre-Alcohol helps your nights. Sugar-to-Fiber helps your mornings by turning excess sugar into prebiotic fiber. Together they support all-day performance.