


A new probiotic engineered for when you drink
Using the power of genetic engineering, Pre-Alcohol makes miserable mornings after drinking a thing of the past.
Pre-Alcohol
Pre-Alcohol
ZBiotics® Pre-Alcohol Probiotic Drink breaks down an unwanted alcohol byproduct called acetaldehyde – the primary culprit behind rough mornings after drinking.
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Meet our lead scientists
For easier mornings after drinking


You probably have some questions
We deal with some complex subject matter. Here are some common questions we get about who we are and what we do.
ZBiotics Pre-Alcohol (or Pre-Alcohol for short) is a beverage containing a patented, genetically engineered probiotic (B. subtilis ZB183™) that helps you land on your feet the day after drinking alcohol. It’s engineered to break down an unwanted byproduct of alcohol called acetaldehyde – the main culprit behind rough mornings after drinking (citation).*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Other products on the market today are different mixes of the same ~10 off-the-shelf vitamins and plant extracts you can find anywhere. Many of these have absolutely no demonstration of efficacy or even really a hypothesis as to how they could possibly help you.
Pre-Alcohol is different. We looked at one of the major unwanted byproducts of drinking alcohol – acetaldehyde – and invented a probiotic bacteria to break it down the same way your liver does.
No other product out there does that.
- Drink 1 bottle of Pre-Alcohol.
- Enjoy your night.
- Get some sleep.
Drink Pre-Alcohol before or during drinking – the earlier the better. Just give it a shake and drink the whole thing. The probiotics are designed to become active while you drink and while you sleep, helping your body digest acetaldehyde as they’re passing through your gut. Then they simply leave your body after a day or two, without changing your body or impacting your microbiome. A happier, healthier you, thanks to ZBiotics Pre-Alcohol.
Interestingly, there is really good science that clearly debunks the persistent myth that alcohol causes dehydration, and that dehydration is responsible for how you feel the next day. Alcohol does not significantly dehydrate you, and there are many academic studies confirming this over the past several decades (citation). We did a write-up about alcohol and dehydration (with citations) we recommend reading.
In general though, you can do a simple thought experiment to prove to yourself that any rough feelings you have the day after drinking have nothing to do with dehydration: 1. If how you felt the next day really was due to dehydration, then a glass or two of water the next day would make you feel 100% again, which we all know from experience is not at all the case! 2. Things that DO cause dehydration (e.g. eating salty foods, working out) don't make you feel ANYTHING like the way we feel the day after drinking alcohol!
Instead, there are quite a few other things going on in your body when you drink. Here's a great review of the scientific literature on the subject. Acetaldehyde is a key factor, and one requiring an enzymatic approach to deal with. This is why we built ZBiotics Pre-Alcohol: a probiotic engineered to produce the same type of enzyme as your liver to break down acetaldehyde.
One rarely appreciated fact is that your gut, and particularly your colon (part of your gut), is actually a huge sink and source of acetaldehyde in the body, even more so than the blood or liver. In fact, acetaldehyde concentrations in the colon are 10 to 100 times higher than in the blood (citation, citation). That’s because a large amount of acetaldehyde is actually created in your gut, produced by enzymes in both your intestinal lining and your microbiome (citation).
But acetaldehyde doesn’t just stick around your gut. It’s an extremely soluble molecule. So soluble, in fact, that it can actually diffuse into all the fluid of your body, easily passing through membranes from your gut and into your brain, muscles, and cells. The result? All those non-gut effects of acetaldehyde may in fact be quite gut-related.